hrp0089rfc8.4 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2018

Establishing Age, Sex, and Method Related Reference Ranges for Anogenital Distance - a Marker of In Utero Androgen Action

Ljubicic Marie Lindhardt , Thankamony Ajay , Acerini Carlo , Jensen Tina Kold , Main Katharina M , Petersen Jorgen Holm , Busch Alexander S , Upners Emmie , Hagen Casper P , Swan Shanna H , Juul Anders

Background: Anogenital distance (AGD) is an indicator of androgen action in utero. Reduced AGD has been found in males with hypospadias, cryptorchidism, low semen quality and infertility. Its usefulness as a clinical marker in patients with Disorders of Sex Development (DSD) is currently being investigated. However, detailed age, sex and method related reference ranges do not exist. Whether individual (body-size-adjusted) AGD is stable postnatally also remains to be e...